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MMP21 Related Area

MMP21 Related Pathways

    MMP21 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    MMP21 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    MMP21 Summary & Protein Information

    MMP21 Background

    Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000250};; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    Subcellular location: Secreted {ECO:0000305}.
    Tissue specificity: Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines. {ECO:0000269|PubMed:12490321, ECO:0000269|PubMed:12617721}.
    Post-translational: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
    Sequence similarity: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    MMP21 Alternative Name

    MMP-21, [homo-sapiens]
    b2b2458Clo,b2b873Clo, [Mouse]
    b2b873Clo,b2b2458Clo, [mus-musculus]

    MMP21 Related Studies

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