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TFRC/CD71  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
11020-H07H-50
11020-H07H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50741-M07H-50
50741-M07H-100
50 µg 
100 µg 
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Expression host: Human Cells  
90253-C07H-50
90253-C07H-100
50 µg 
100 µg 
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TFRC/CD71 Related Area

TFRC/CD71 Related Pathways

    TFRC/CD71 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    TFRC/CD71 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    TFRC/CD71 Summary & Protein Information

    TFRC/CD71 Background

    Subunit structure: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:17287727}.
    Subcellular location: Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Transferrin receptor protein 1, serum form: Secreted.
    Induction: Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.
    Post-translational: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. {ECO:0000269|PubMed:1421756, ECO:0000269|PubMed:1421757, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:3582362}.; Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).; Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. {ECO:0000269|PubMed:3582362}.
    Sequence similarity: Belongs to the peptidase M28 family. M28B subfamily. {ECO:0000305}.; Contains 1 PA (protease associated) domain. {ECO:0000305}.
    General information above from UniProt

    Mouse transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

    TFRC/CD71 Alternative Name

    TR,T9,TFR,CD71,TFR1,TRFR,P90, [homo-sapiens]
    TFR,Transferrin Receptor,CD71,TFR1,TFRC,TRFR, [human]
    Mtvr-1,TFR,Transferrin Receptor,Trfr,2610028K12Rik,AI195355,AI426448,AU015758,TR,CD71,E430033M20Rik,Mtvr1,p90,TFR1,Tfrc, [mouse]
    Tr,TFR,p90,CD71,TFR1,Trfr,Mtvr1,Mtvr-1,AI195355,AI426448,AU015758,2610028K12Rik,E430033M20Rik, [mus-musculus]

    TFRC/CD71 Related Studies

  • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
  • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
  • Tosoni D., et al., 2005, Cell 123:875-888.
  • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"