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TRAIL R1/CD261/TNFRSF10A  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10408-H03H-200
10408-H03H-100
200 µg 
100 µg 
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Expression host: Human Cells  
10408-H02H-200
10408-H02H-100
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100 µg 
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Expression host: Human Cells  
10408-H08H-200
10408-H08H-100
200 µg 
100 µg 
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TRAIL R1/CD261/TNFRSF10A Related Area

TRAIL R1/CD261/TNFRSF10A Related Pathways

TRAIL R1/CD261/TNFRSF10A Related Protein, Antibody, cDNA Gene, and ELISA Kits

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TRAIL R1/CD261/TNFRSF10A Summary & Protein Information

TRAIL R1/CD261/TNFRSF10A Background

Gene Summary: The TRAIL R1 protein encoded by this TNFRSF10A gene is a member of the TNF-receptor superfamily. TRAIL R1 is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by TRAIL R1.
General information above from NCBI
Subunit structure: Can interact with TRADD and RIPK1. Interacts with ARAP1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10A cell surface expression. {ECO:0000269|PubMed:18165900, ECO:0000269|PubMed:23498957}.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Sequence similarity: Contains 1 death domain. {ECO:0000255|PROSITE-ProRule:PRU00064}.; Contains 3 TNFR-Cys repeats. {ECO:0000255|PROSITE-ProRule:PRU00206}.
General information above from UniProt

Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.

TRAIL R1/CD261/TNFRSF10A Alternative Name

TRAIL R1/CD261/TNFRSF10A Related Studies

  • Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
  • Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.
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