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TNFSF14/LIGHT/CD258  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
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TNFSF14/LIGHT/CD258 Related Protein, Antibody, cDNA Gene, and ELISA Kits

TNFSF14/LIGHT/CD258 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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TNFSF14/LIGHT/CD258 Summary & Protein Information

TNFSF14/LIGHT/CD258 Related Information

TNFSF14/LIGHT/CD258 Background

Gene Summary: The protein encoded by this TNFSF14 gene is a member of the tumor necrosis factor (TNF) ligand family. TNFSF14 is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). TNFSF14 may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. TNFSF14 has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. TNFSF14 is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
General information above from NCBI
Subunit structure: Homotrimer.
Subcellular location: Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.; Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.; Isoform 2: Cytoplasm.
Tissue specificity: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
Induction: Up-regulated after T-cell activation.
Post-translational: N-glycosylated. {ECO:0000269|Ref.9}.; The soluble form of isoform 1 derives from the membrane form by proteolytic processing. {ECO:0000269|PubMed:11673523}.
Sequence similarity: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14 / LIGHT / CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβR), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14 / LIGHT / CD258 also binds to a soluble nonsignaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14 / LIGHT / CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4+ and CD8+ T cells. In addition, TNFSF14 / LIGHT / CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14 / LIGHT / CD258 is being actively investigated as a possible basis for cancer treatment.

TNFSF14/LIGHT/CD258 Alternative Name

TNFSF14/LIGHT/CD258 Related Studies

  • Ogawa T, et al. (2010) CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis. J Urol. 183(3): 1206-12.
  • Kanodia S, et al. (2010) Expression of LIGHT/TNFSF14 combined with vaccination against human papillomavirus Type 16 E7 induces significant tumor regression. Cancer Res. 70(10): 3955-64.
  • Hosokawa Y, et al. (2010) TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts. Mol Immunol. 47(4): 666-70.