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TRAIL/TNFSF10  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: E. coli  
10409-HNAE-50
10409-HNAE-100
10409-HNAE-10
50 µg 
100 µg 
10 µg 
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Expression host: E. coli  
50166-M07E-50
50166-M07E-100
50 µg 
100 µg 
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Expression host: E. coli  
90098-CNAE-50
90098-CNAE-100
90098-CNAE-10
50 µg 
100 µg 
10 µg 
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TRAIL/TNFSF10 Summary & Protein Information

TRAIL/TNFSF10 Background

Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 1 zinc ion per trimer.;
Subunit structure: Homotrimer.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue specificity: Widespread; most predominant in spleen, lung and prostate.
Post-translational: Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
Sequence similarity: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion TNFSF10 / Apo-2L / CD253 / TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A / TRAILR1, TNFRSF10B / TRAILR2, TNFRSF10C / TRAILR3, TNFRSF10D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 / TRAIL may be modulated by binding to the decoy receptors TNFRSF10C / TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8 / JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

TRAIL/TNFSF10 Alternative Name

TL2,APO2L,CD253,TRAIL,Apo-2L, [homo-sapiens]
APO2L,Apo-2L,CD253,TL2,TNFSF10,TRAIL, [human]
A330042I21Rik,AI448571,APO-2L,Ly81,TL2,Tnfsf10,Trail, [mouse]
TL2,Ly81,Trail,APO-2L,AI448571,A330042I21Rik, [mus-musculus]

TRAIL/TNFSF10 Related Studies

  • Song C, et al. (2005) TRAIL (CD253), a new member of the TNF superfamily. J Biol Regul Homeost Agents. 19(1-2): 73-7.
  • Kuribayashi K, et al. (2008) TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther. 7(12): 2034-8.
  • Wiley SR, et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 3(6): 673-82.
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