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TIM-3/HAVCR2   Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
10390-H03H-50
10390-H03H-100
50 µg 
100 µg 
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Expression host: Human Cells  
10390-H08H-50
10390-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
51152-M08H-50
51152-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
51152-M02H-50
51152-M02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
90312-C02H-50
90312-C02H-100
50 µg 
100 µg 
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TIM-3/HAVCR2  Related Area

TIM-3/HAVCR2  Related Pathways

    TIM-3/HAVCR2  Related Protein, Antibody, cDNA Gene, and ELISA Kits

    TIM-3/HAVCR2  Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    TIM-3/HAVCR2  Summary & Protein Information

    TIM-3/HAVCR2  Background

    Gene Summary: The protein encoded by HAVCR2 gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
    General information above from NCBI
    Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
    Tissue specificity: T-helper type 1 lymphocyte (Th1)-specific.
    Post-translational: O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:22171320}.
    Sequence similarity: Belongs to the immunoglobulin superfamily. TIM family. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In tumor rejection model, soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.

    TIM-3/HAVCR2  Alternative Name

    TIM-3/HAVCR2  Related Studies

  • Geng H, et al. (2006) Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J Immunol. 176(3): 1411-20.
  • Anderson AC, et al. (2006) TIM-3 in autoimmunity. Curr Opin Immunol. 18(6): 665-9.
  • Anderson DE. (2007) TIM-3 as a therapeutic target in human inflammatory diseases. Expert Opin Ther Targets. 11(8): 1005-9.
  • Pan HF, et al. (2010) TIM-3 as a new therapeutic target in systemic lupus erythematosus. Mol Biol Rep. 37(1): 395-8.
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