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TIGIT/VSTM3  Protein, Antibody, ELISA Kit, cDNA Clone

Description:   
Expression host: Human Cells  
10917-H08H-50
10917-H08H-20
10917-H08H-10
50 µg 
20 µg 
10 µg 
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Expression host: Human Cells  
50939-M08H-50
50939-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50939-M02H-50
50939-M02H-100
50 µg 
100 µg 
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TIGIT/VSTM3 Related Pathways

    TIGIT/VSTM3 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    TIGIT/VSTM3 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    TIGIT/VSTM3 Summary & Protein Information

    TIGIT/VSTM3 Background

    Gene Summary: TIGIT gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of TIGIT gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
    General information above from NCBI
    Subunit structure: Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to PVRL2 and PVRL3. {ECO:0000269|PubMed:22421438}.
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    Subcellular location: Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.
    Tissue specificity: Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). {ECO:0000269|PubMed:19011627}.
    Sequence similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-10 and diminished the production of IL-12p40. In addition, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.

    TIGIT/VSTM3 Alternative Name

    TIGIT/VSTM3 Related Studies

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