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Syndecan-1/CD138/SDC1  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
11429-H08H-50
11429-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50641-M08H-50
50641-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
80344-R02H-50
80344-R02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
80344-R08H-50
80344-R08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

Syndecan-1/CD138/SDC1 Related Area

Syndecan-1/CD138/SDC1 Related Pathways

Syndecan-1/CD138/SDC1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

Syndecan-1/CD138/SDC1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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Syndecan-1/CD138/SDC1 Summary & Protein Information

Syndecan-1/CD138/SDC1 Background

Subunit structure: Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). {ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:23395182}.
Subcellular location: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.
Post-translational: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Sequence similarity: Belongs to the syndecan proteoglycan family. {ECO:0000305}.
General information above from UniProt

Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

Syndecan-1/CD138/SDC1 Alternative Name

SDC,CD138,SYND1,syndecan, [homo-sapiens]
CD138,SDC1,Syndecan-1,SDC,SYND1,syndecan, [human]
CD138,Sstn,syndecan,Syndecan-1,AA408134,AA409076,Sdc1,syn-1,Synd,Synd1, [mouse]
Sstn,Synd,CD138,Synd1,syn-1,AA408134,AA409076, [mus-musculus]

Syndecan-1/CD138/SDC1 Related Studies

  • Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
  • Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
  • Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.
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