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SIRPA/SIRP alpha/CD172a  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
11612-H08H-50
11612-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50956-M08H-50
50956-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50956-M02H-50
50956-M02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
80270-R08H-50
80270-R08H-100
50 µg 
100 µg 
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SIRPA/SIRP alpha/CD172a Related Area

SIRPA/SIRP alpha/CD172a Related Pathways

    SIRPA/SIRP alpha/CD172a Related Protein, Antibody, cDNA Gene, and ELISA Kits

    SIRPA/SIRP alpha/CD172a Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    SIRPA/SIRP alpha/CD172a Summary & Protein Information

    SIRPA/SIRP alpha/CD172a Background

    Subunit structure: Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. {ECO:0000250, ECO:0000269|PubMed:18657508}.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Tissue specificity: Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
    Post-translational: N-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9062191}.; Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11. {ECO:0000269|PubMed:10842184, ECO:0000269|PubMed:9062191}.
    Sequence similarity: Contains 2 Ig-like C1-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.

    SIRPA/SIRP alpha/CD172a Alternative Name

    BIT,MFR,P84,SIRP,MYD-1,SHPS1,CD172A,PTPNS1, [homo-sapiens]
    BIT,CD172A,MFR,MYD-1,P84,PTPNS1,SHPS1,SIRP,SIRP alpha, [human]
    AI835480,Bit,CD172a,P84,Ptpns1,RP23-37B4.2,SHP-1,SHPS-1,SIRP,SIRP alpha, [mouse]
    p84,SHP-1,Bit,SIRP,CD172a,Ptpns1,SHPS-1,AI835480, [mus-musculus]

    SIRPA/SIRP alpha/CD172a Related Studies

  • Timms JF. et al., 1999, Curr Biol. 9: 927-30.
  • Stofega MR. et al., 2000, J Biol Chem. 275: 28222-9.
  • Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
  • Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"