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R-Spondin 1/RSPO1  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
11083-H08H-5
11083-H08H-20
11083-H08H-100
5 µg 
20 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
11083-H08H1-50
11083-H08H1-20
50 µg 
20 µg 
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Expression host: CHO Stable Cells  
11083-HNAS-500
11083-HNAS-5
11083-HNAS-20
11083-HNAS-100
11083-HNAS-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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Description: Active  
Expression host: CHO Stable Cells  
50316-M08S-5
50316-M08S-20
50316-M08S-100
5 µg 
20 µg 
100 µg 
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  • Slide 1

R-Spondin 1/RSPO1 Related Area

R-Spondin 1/RSPO1 Related Pathways

R-Spondin 1/RSPO1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

R-Spondin 1/RSPO1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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R-Spondin 1/RSPO1 Summary & Protein Information

R-Spondin 1/RSPO1 Background

Subunit structure: Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity). Interacts with ZNRF3; promoting indirect interaction between ZNRF3 and LGR4 and membrane clearance of ZNRF3. Interacts with LGR4, LGR5 and LGR6. Identified in a complex composed of RNF43, LGR5 and RSPO1. {ECO:0000250, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23756651, ECO:0000269|PubMed:23756652, ECO:0000269|PubMed:23809763}.
Domain: The FU repeats are required for activation and stabilization of beta-catenin. {ECO:0000250}.
Subcellular location: Secreted {ECO:0000250}.
Tissue specificity: Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. {ECO:0000269|PubMed:17041600}.
Involvement in disease: DISEASE: Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:610644]: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the R-spondin family. {ECO:0000305}.; Contains 2 FU (furin-like) repeats. {ECO:0000305}.; Contains 1 TSP type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00210}.
General information above from UniProt

RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.

R-Spondin 1/RSPO1 Alternative Name

RSPO,CRISTIN3, [homo-sapiens]
R-Spondin 1, [Human]
RP23-325M14.2,Rspo1,Rspondin,R-spondin, [mouse]
Rspondin,R-spondin, [mus-musculus]

R-Spondin 1/RSPO1 Related Studies

  • Kamata T, et al. (2004) R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta. 1676(1):51-62.
  • Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36(1):40-5.
  • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
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