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PIK3CB  Protein, Antibody, ELISA Kit, cDNA Clone

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    PIK3CB Summary & Protein Information

    PIK3CB Background

    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
    Subunit structure: Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By similarity). {ECO:0000250}.
    Domain: The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival.
    Subcellular location: Cytoplasm {ECO:0000269|PubMed:21383062}. Nucleus {ECO:0000269|PubMed:21383062}. Note=Interaction with PIK3R2 is required for nuclear localization and export.
    Tissue specificity: Expressed ubiquitously.
    Post-translational: Phosphorylation at Ser-1070 down-regulates lipid kinase activity. {ECO:0000269|PubMed:12502714}.
    Sequence similarity: Belongs to the PI3/PI4-kinase family. {ECO:0000255|PROSITE-ProRule:PRU00877, ECO:0000255|PROSITE-ProRule:PRU00879, ECO:0000255|PROSITE-ProRule:PRU00880}.; Contains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE-ProRule:PRU00880}.; Contains 1 PI3K-ABD domain. {ECO:0000255|PROSITE-ProRule:PRU00877}.; Contains 1 PI3K-RBD domain. {ECO:0000255|PROSITE-ProRule:PRU00879}.; Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE-ProRule:PRU00269}.; Contains 1 PIK helical domain. {ECO:0000255|PROSITE-ProRule:PRU00878}.
    General information above from UniProt

    PIK3CB Alternative Name

    PI3K,PIK3C1,P110BETA,PI3KBETA, [homo-sapiens]
    P110BETA,PI3K,PI3KBETA,PIK3C1, [Human]
    1110001J02Rik,AI447572,p110beta, [Mouse]
    AI447572,p110beta,1110001J02Rik, [mus-musculus]

    PIK3CB Related Studies

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