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PD-L1/B7-H1/CD274  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
10084-H05H-20
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    Expression host: Human Cells  
    10084-H02H-200
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    Expression host: Human Cells  
    10084-H08H-200
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    Expression host: Human Cells  
    50010-M03H-200
    50010-M03H-100
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    Description: Active  
    Expression host: Human Cells  
    50010-M08H-200
    50010-M08H-100
    200 µg 
    100 µg 
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    Expression host: Human Cells  
    50010-M02H-200
    50010-M02H-100
    200 µg 
    100 µg 
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    Expression host: Human Cells  
    80450-R02H-200
    80450-R02H-100
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    Expression host: Human Cells  
    80450-R08H-200
    80450-R08H-100
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    Expression host: Human Cells  
    90251-C08H-200
    90251-C08H-100
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    Expression host: Human Cells  
    90251-C02H-200
    90251-C02H-100
    200 µg 
    100 µg 
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    Expression host: Human Cells  
    70110-D02H-200
    70110-D02H-100
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    PD-L1/B7-H1/CD274 Related Area

    lyy test-Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers. lyytest

    PD-L1/B7-H1/CD274 Related Pathways

      PD-L1/B7-H1/CD274 Related Protein, Antibody, cDNA Gene, and ELISA Kits

      PD-L1/B7-H1/CD274 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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      PD-L1/B7-H1/CD274 Summary & Protein Information

      PD-L1/B7-H1/CD274 Background

      Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

      PD-L1/B7-H1/CD274 Alternative Name

      PD-L1/B7-H1/CD274 Related Studies

    • Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7.
    • Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.
    • Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.
    • Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.
    • Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.
    • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"