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OX40/TNFRSF4/CD134  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
10481-H03H-50
10481-H03H-100
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Description: Active  
Expression host: Human Cells  
10481-H08H-50
10481-H08H-100
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Expression host: Human Cells  
50808-M02H-50
50808-M02H-100
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100 µg 
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Expression host: Human Cells  
90846-C08H-50
90846-C08H-200
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200 µg 
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Expression host: Human Cells  
90846-C02H-50
90846-C02H-200
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OX40/TNFRSF4/CD134 Related Area

OX40/TNFRSF4/CD134 Related Pathways

OX40/TNFRSF4/CD134 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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OX40/TNFRSF4/CD134 Summary & Protein Information

OX40/TNFRSF4/CD134 Background

Gene Summary: OX40, the protein encoded by this TNFRSF4 gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that OX40 promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
General information above from NCBI
Subunit structure: Interacts with TRAF2, TRAF3 and TRAF5. {ECO:0000269|PubMed:16905106, ECO:0000269|PubMed:9418902, ECO:0000269|PubMed:9488716}.
Subcellular location: Membrane; Single-pass type I membrane protein.
Involvement in disease: DISEASE: Immunodeficiency 16 (IMD16) [MIM:615593]: An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency. {ECO:0000269|PubMed:23897980}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Contains 4 TNFR-Cys repeats. {ECO:0000255|PROSITE-ProRule:PRU00206}.
General information above from UniProt

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.

OX40/TNFRSF4/CD134 Alternative Name

OX40/TNFRSF4/CD134 Related Studies

  • Compaan D.M., et al. (2006) .The crystal structure of the costimulatory OX40-OX40L complex. Structure 14:1321-1330.
  • Kawamata S., et al. (1998) .Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273:5808-5814.
  • Byun M., (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J. Exp. Med. 210:1743-1759.
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