Myelin oligodendrocyte glycoprotein
Protein, Antibody, ELISA Kit, cDNA Clone Myelin oligodendrocyte glycoprotein Related Area Myelin oligodendrocyte glycoprotein Related Protein, Antibody, cDNA Gene, and ELISA Kits Myelin oligodendrocyte glycoprotein Related Protein, Antibody, cDNA Gene, and ELISA Kits Featured Reagent Products Myelin oligodendrocyte glycoprotein Background
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.