Quick Order

Home>MMP16
Text Size:AAA

MMP-16  Protein, Antibody, ELISA Kit, cDNA Clone

MMP-16 Related Area

MMP-16 Related Pathways

    MMP-16 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    MMP-16 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Featured Reagent Products

    MMP-16 Summary & Protein Information

    MMP-16 Background

    Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000250};; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
    Enzyme regulation: ENZYME REGULATION: TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.
    Subunit structure: Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. {ECO:0000269|PubMed:11278606, ECO:0000269|PubMed:14741217}.
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    Subcellular location: Isoform Long: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells.; Isoform Short: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.
    Tissue specificity: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
    Developmental stage: Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
    Post-translational: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
    Sequence similarity: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    MMP-16 Alternative Name

    MMP-16 Related Studies

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"