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MBP/Myelin Basic Protein  Protein, Antibody, ELISA Kit, cDNA Clone

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    MBP/Myelin Basic Protein Related Protein, Antibody, cDNA Gene, and ELISA Kits

    MBP/Myelin Basic Protein Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    MBP/Myelin Basic Protein Summary & Protein Information

    MBP/Myelin Basic Protein Background

    Subunit structure: Homodimer. Isoform 3 exists as a homodimer. {ECO:0000269|PubMed:11080454, ECO:0000269|PubMed:11163233, ECO:0000269|PubMed:16079912}.
    Subcellular location: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.; Isoform 3: Nucleus {ECO:0000269|PubMed:22609403}. Note=Targeted to nucleus in oligodendrocytes.
    Tissue specificity: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. {ECO:0000269|PubMed:7504278}.
    Developmental stage: Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its relative proportion declines thereafter.
    Post-translational: Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic. {ECO:0000269|PubMed:23828821, ECO:0000269|PubMed:2466844, ECO:0000269|PubMed:5128665}.; The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).; Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.; Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.
    Involvement in disease: DISEASE: Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
    Sequence similarity: Belongs to the myelin basic protein family. {ECO:0000305}.
    General information above from UniProt

    MBP/Myelin Basic Protein Alternative Name

    C76307,golli-mbp,Hmbpr,mld,R75289,shi, [Mouse]
    mld,shi,Hmbpr,C76307,R75289,golli-mbp, [mus-musculus]

    MBP/Myelin Basic Protein Related Studies

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