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Activin A  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
10429-HNAH-50
10429-HNAH-10
50 µg 
10 µg 
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Description: Active  
Expression host: Human Cells  
50659-M08H-20
50659-M08H-10
20 µg 
10 µg 
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Activin A Related Area

Activin A Related Pathways

Activin A Related Protein, Antibody, cDNA Gene, and ELISA Kits

Activin A Related Protein, Antibody, cDNA Gene, and ELISA Kits

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Activin A Summary & Protein Information

Activin A Background

Subunit structure: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3. {ECO:0000269|PubMed:12660162, ECO:0000269|PubMed:12697670, ECO:0000269|PubMed:18768470}.
Subcellular location: Secreted.
Sequence similarity: Belongs to the TGF-beta family. {ECO:0000305}.
General information above from UniProt

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two β subunits, βA βA (activin A), βB βB (activin B), or βA βB (activin AB). Inhibin is composed of an alpha and one of two β subunits, βA (inhibin A) or βB (inhibin B). Activins are produced in many cell types and organs, such as gonads, pituitary gland, and placenta. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis. In addition, Activin plays a role in wound repair and skin morphogenesis. Activin is strongly expressed in wounded skin, and overexpression of activin in epidermis of transgenic mice improves wound healing and enhances scar formation. Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and kidney. There is also evidence showed that lack of activin during development results in neural developmental defects.

Activin A Alternative Name

EDF,FRP, [homo-sapiens]
EDF,FRP,INHBA, [human]
activin,Inhba,inhibin beta A, [mouse]

Activin A Related Studies

  • Tanimoto K, et al. (1992) Structure and sequence analysis of the human activin beta A subunit gene. DNA Seq. 2 (2): 103-10.
  • Welt C, et al. (2002) Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. Exp Biol Med. 227 (9): 724-52.
  • Xu J, et al. (1995) Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem. 270 (11): 6308-13.
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