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CD18/Integrin beta 2/ITGB2  Protein, Antibody, ELISA Kit, cDNA Clone

CD18/Integrin beta 2/ITGB2 Related Area

CD18/Integrin beta 2/ITGB2 Related Pathways

    CD18/Integrin beta 2/ITGB2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CD18/Integrin beta 2/ITGB2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CD18/Integrin beta 2/ITGB2 Summary & Protein Information

    CD18/Integrin beta 2/ITGB2 Background

    Subunit structure: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9. {ECO:0000250, ECO:0000269|PubMed:10766246, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:20033057}.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Post-translational: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins. {ECO:0000269|PubMed:11700305}.
    Involvement in disease: DISEASE: Leukocyte adhesion deficiency 1 (LAD1) [MIM:116920]: LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. {ECO:0000269|PubMed:1346613, ECO:0000269|PubMed:1347532, ECO:0000269|PubMed:1352501, ECO:0000269|PubMed:1590804, ECO:0000269|PubMed:1694220, ECO:0000269|PubMed:1968911, ECO:0000269|PubMed:20529581, ECO:0000269|PubMed:20549317, ECO:0000269|PubMed:7509236, ECO:0000269|PubMed:7686755, ECO:0000269|PubMed:9884339}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the integrin beta chain family. {ECO:0000305}.; Contains 1 VWFA domain. {ECO:0000305}.
    General information above from UniProt

    CD18/Integrin beta 2/ITGB2 Alternative Name

    LFA-1,MAC-1,CD18,MF17,MFI7,LCAMB,LAD, [homo-sapiens]
    2000000,LAD,Cd18,Lfa1,MF17,LCAMB,AI528527, [mus-musculus]

    CD18/Integrin beta 2/ITGB2 Related Studies

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