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IL-5/IL5 / Interleukin 5  Protein, Antibody, ELISA Kit, cDNA Clone

Description:   
Expression host: E. coli  
15673-HNCE-5
15673-HNCE-20
15673-HNCE-100
5 µg 
20 µg 
100 µg 
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Description: Active  
Expression host: Baculovirus-Insect Cells  
51068-M08B-5
51068-M08B-20
51068-M08B-100
5 µg 
20 µg 
100 µg 
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  • Slide 1
Expression host: Baculovirus-Insect Cells  
70019-D08B-5
70019-D08B-20
70019-D08B-100
5 µg 
20 µg 
100 µg 
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  • Slide 1

IL-5/IL5 / Interleukin 5 Related Area

IL-5/IL5 / Interleukin 5 Related Pathways

    IL-5/IL5 / Interleukin 5 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    IL-5/IL5 / Interleukin 5 Summary & Protein Information

    IL-5/IL5 / Interleukin 5 Background

    Subunit structure: Homodimer; disulfide-linked. {ECO:0000269|PubMed:2037074, ECO:0000269|PubMed:22153509, ECO:0000269|PubMed:2361960, ECO:0000269|PubMed:8483502}.
    Subcellular location: Secreted.
    Sequence similarity: Belongs to the IL-5 family. {ECO:0000305}.
    General information above from UniProt

    Interleukin 5 (IL-5) is a member of the interleukin family with length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins / signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered as a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival.

    IL-5/IL5 / Interleukin 5 Alternative Name

    EDF,TRF,IL-5, [homo-sapiens]
    TRF,EDF,IL-5, [human]
    RP23-239O19.2,Il-5, [mouse]
    Il-5, [mus-musculus]

    IL-5/IL5 / Interleukin 5 Related Studies

  • Milburn MV, et al. (1993) A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. 363(6425): 172-176.
  • Lee JS, et al. (1989) The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11. Somat Cell Mol Genet. 15(2): 143-152.
  • Woodcock JM, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13 (21): 5176-85.
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