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IL17A/IL-17A/IL17  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Baculovirus-Insect Cells  
12047-H07B-50
12047-H07B-5
12047-H07B-20
12047-H07B-100
50 µg 
5 µg 
20 µg 
100 µg 
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Expression host: E. coli  
12047-HNAE-5
12047-HNAE-20
12047-HNAE-100
5 µg 
20 µg 
100 µg 
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Expression host: Yeast  
12047-H07Y-50
12047-H07Y-100
50 µg 
100 µg 
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Expression host: CHO Stable Cells  
12047-HNAS-500
12047-HNAS-5
12047-HNAS-20
12047-HNAS-100
12047-HNAS-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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Description: Active  
Expression host: E. coli  
51065-MNAE-50
51065-MNAE-20
50 µg 
20 µg 
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Expression host: E. coli  
70102-DNAE-50
70102-DNAE-100
50 µg 
100 µg 
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Expression host: Baculovirus-Insect Cells  
90306-KNAB-20
90306-KNAB-100
20 µg 
100 µg 
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  • Slide 1
Description:   
Expression host: Baculovirus-Insect Cells  
65006-T07B-5
65006-T07B-20
65006-T07B-100
5 µg 
20 µg 
100 µg 
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Expression host: E. coli  
90287-CNAE-50
90287-CNAE-100
50 µg 
100 µg 
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  • Slide 1

IL17A/IL-17A/IL17 Related Area

IL17A/IL-17A/IL17 Related Pathways

    IL17A/IL-17A/IL17 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    IL17A/IL-17A/IL17 Summary & Protein Information

    IL17A/IL-17A/IL17 Background

    Subunit structure: Homodimer. {ECO:0000269|PubMed:19835883}.
    Subcellular location: Secreted.
    Tissue specificity: Restricted to activated memory T-cells.
    Post-translational: Found both in glycosylated and nonglycosylated forms.
    Sequence similarity: Belongs to the IL-17 family. {ECO:0000305}.
    General information above from UniProt

    IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

    IL17A/IL-17A/IL17 Alternative Name

    IL17,CTLA8,IL-17,IL-17A, [homo-sapiens]
    CTLA8,CTLA-8,cytotoxic T-lymphocyte-associated antigen 8,cytotoxic T-lymphocyte-associated protein 8,cytotoxic T-lymphocyte-associated serine esterase 8,IL17,IL-17,IL-17A,interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8),interleukin-17A, [human]
    Ctla8,Ctla-8,cytotoxic T-lymphocyte-associated antigen 8. interleukin-17A,Il17,IL-17,IL-17A, [mouse]
    Il17,Ctla8,IL-17,Ctla-8,IL-17A, [mus-musculus]

    IL17A/IL-17A/IL17 Related Studies

  • Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
  • Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
  • Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
  • Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.
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