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IL12A / IL-12A  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
10021-H02H-50
10021-H02H-20
50 µg 
20 µg 
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Description: Active  
Expression host: Human Cells  
10021-H08H-500
10021-H08H-5
10021-H08H-20
10021-H08H-100
10021-H08H-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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Expression host: Human Cells  
90290-C02H-50
90290-C02H-20
50 µg 
20 µg 
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IL12A / IL-12A Related Area

IL12A / IL-12A Related Pathways

    IL12A / IL-12A Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    IL12A / IL-12A Summary & Protein Information

    IL12A / IL-12A Background

    Gene Summary: This IL-12A gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
    General information above from NCBI
    Subunit structure: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12. {ECO:0000269|PubMed:10899108}.
    Subcellular location: Secreted.
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection. {ECO:0000269|PubMed:16548883}.
    Sequence similarity: Belongs to the IL-6 superfamily. {ECO:0000305}.
    General information above from UniProt

    Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 alpha chain. IL12A/IL-12p35 is a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. IL12A/IL-12p35 is required for the T-cell-independent induction of IFN-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. In clinical, IL-12 remains a very promising immunotherapeutic agent because recent cancer vaccination studies in animal models and humans have demonstrated its powerful adjuvant properties. The immune modulating characteristics of IL-12 considered responsible for the adjuvant effects, as well as the results of animal and human cancer vaccination studies with IL-12 applied as an adjuvant. IL12A/IL-12p35 indicates a cytokine which is important in the development of prostate cancer.

    IL12A / IL-12A Alternative Name

    IL12A / IL-12A Related Studies

  • Sattler HP, et al. (2000) Novel amplification unit at chromosome 3q25-q27 in human prostate cancer. Prostate. 45(3): 207-15.
  • Lamont AG, et al. (1996) IL-12: a key cytokine in immune regulation. Immunol Today. 17(5): 214-7.
  • Portielje JE, et al. (2003) IL-12: a promising adjuvant for cancer vaccination. Cancer Immunol Immunother. 52(3): 133-44.
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