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IL6R/IL-6R/CD126  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10398-H08H-50
10398-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50280-M08H-50
50280-M08H-20
50 µg 
20 µg 
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Expression host: Human Cells  
81072-R08H-50
81072-R08H-20
50 µg 
20 µg 
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Expression host: Human Cells  
81072-R02H-20
81072-R02H-100
20 µg 
100 µg 
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Expression host: Human Cells  
70117-D08H-5
70117-D08H-20
70117-D08H-100
5 µg 
20 µg 
100 µg 
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IL6R/IL-6R/CD126 Related Area

IL6R/IL-6R/CD126 Related Pathways

    IL6R/IL-6R/CD126 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    IL6R/IL-6R/CD126 Summary & Protein Information

    IL6R/IL-6R/CD126 Background

    Subunit structure: Hexamer of two molecules each of IL6, IL6R and IL6ST.
    Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.; The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    Subcellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
    Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
    Post-translational: A short soluble form may also be released from the membrane by proteolysis.
    Sequence similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily. {ECO:0000305}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

    IL6R/IL-6R/CD126 Alternative Name

    CD126,IL6R,IL-6R,IL-6R-1,IL6RA,IL-6R-alpha,MGC104991, [human]

    IL6R/IL-6R/CD126 Related Studies

  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
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