Quick Order

Home>IL6
Text Size:AAA

IL6/IL-6/Interleukin-6  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: E. coli  
10395-HNAE-500
10395-HNAE-5
10395-HNAE-20
10395-HNAE-100
10395-HNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
  • Slide 1
Description: Active  
Expression host: E. coli  
50136-MNAE-5
50136-MNAE-20
50136-MNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: E. coli  
80076-RNAE-5
80076-RNAE-20
80076-RNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: E. coli  
90197-CNAE-5
90197-CNAE-20
90197-CNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: E. coli  
62006-WNAE-50
62006-WNAE-5
62006-WNAE-20
62006-WNAE-100
50 µg 
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1

IL6/IL-6/Interleukin-6 Related Area

IL6/IL-6/Interleukin-6 Related Pathways

    IL6/IL-6/Interleukin-6 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Featured Reagent Products

    IL6/IL-6/Interleukin-6 Summary & Protein Information

    IL6/IL-6/Interleukin-6 Background

    Subcellular location: Secreted.
    Post-translational: N- and O-glycosylated. {ECO:0000269|PubMed:1883960}.
    Involvement in disease: DISEASE: Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; DISEASE: Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
    Sequence similarity: Belongs to the IL-6 superfamily. {ECO:0000305}.
    General information above from UniProt

    Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

    IL6/IL-6/Interleukin-6 Alternative Name

    HGF,HSF,BSF2,IL-6,IFNB2, [homo-sapiens]
    BSF2,HGF,HSF,IFNB2,IL6,IL-6, [human]
    Il-6, [mus-musculus]

    IL6/IL-6/Interleukin-6 Related Studies

  • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
  • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
  • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"