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IL21/IL-21  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: E. coli  
10584-HNAE-500
10584-HNAE-5
10584-HNAE-20
10584-HNAE-100
10584-HNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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Expression host: E. coli  
50137-MNAE-5
50137-MNAE-20
50137-MNAE-100
5 µg 
20 µg 
100 µg 
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Expression host: Baculovirus-Insect Cells  
80200-R08B-5
80200-R08B-20
80200-R08B-100
5 µg 
20 µg 
100 µg 
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Expression host: E. coli  
70016-DNAE-5
70016-DNAE-20
70016-DNAE-100
5 µg 
20 µg 
100 µg 
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  • Slide 1

IL21/IL-21 Related Area

IL21/IL-21 Related Pathways

    IL21/IL-21 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    IL21/IL-21 Summary & Protein Information

    IL21/IL-21 Background

    Subcellular location: Secreted {ECO:0000269|PubMed:11081504}.
    Tissue specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. {ECO:0000269|PubMed:11081504}.
    Involvement in disease: DISEASE: Immunodeficiency, common variable, 11 (CVID11) [MIM:615767]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:24746753}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
    General information above from UniProt

    IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation)

    IL21/IL-21 Alternative Name

    Za11,IL-21,CVID11, [homo-sapiens]
    IL-21,IL21,Za11, [human]
    DN-452A22.7,Il21,IL-21, [mouse]
    IL-21, [mus-musculus]

    IL21/IL-21 Related Studies

  • Coquet JM, et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34.
  • Wei L, et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10.
  • Parrish-Novak J, et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63. 4 Kuchen S, et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9):5886-96.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"