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IL10/IL-10/Interleukin-10  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
10947-H07H-5
10947-H07H-20
10947-H07H-100
5 µg 
20 µg 
100 µg 
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Expression host: E. coli  
10947-HNAE-500
10947-HNAE-5
10947-HNAE-20
10947-HNAE-100
10947-HNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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Expression host: E. coli  
80082-RNAE-20
80082-RNAE-10
20 µg 
10 µg 
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Expression host: E. coli  
67001-UNAE-5
67001-UNAE-20
67001-UNAE-100
5 µg 
20 µg 
100 µg 
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Expression host: E. coli  
62000-WNAE-5
62000-WNAE-20
62000-WNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1

IL10/IL-10/Interleukin-10 Related Area

IL10/IL-10/Interleukin-10 Related Pathways

    IL10/IL-10/Interleukin-10 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    IL10/IL-10/Interleukin-10 Summary & Protein Information

    IL10/IL-10/Interleukin-10 Background

    Subunit structure: Homodimer. {ECO:0000269|PubMed:11485736, ECO:0000269|PubMed:15837194}.
    Subcellular location: Secreted.
    Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
    Sequence similarity: Belongs to the IL-10 family. {ECO:0000305}.
    General information above from UniProt

    IL-10 is a anti-inflammatory cytokine which belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.

    IL10/IL-10/Interleukin-10 Alternative Name

    CSIF,TGIF,GVHDS,IL-10,IL10A, [homo-sapiens]
    IL10,MGC126451,CSIF,IL-10,IL10A,MGC126450,RP11-262N9.1,TGIF, [human]
    CSIF,Il10,Il-10,AL513351.1, [mouse]
    CSIF,Il-10, [mus-musculus]

    IL10/IL-10/Interleukin-10 Related Studies

  • Arimoto T, et al. (2007) Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging. 28(6):894-906.
  • Han X, et al. (2010) Effect of cobalt protoporphyrin on hyperexpression of heme oxygenase-1 and secretion of IL-10 in rat bone marrow mesenchymal stem cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 18(5):1297-301.
  • Cui QQ, et al. (2011) Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 77(7): 1436-41.
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