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ICOSL/ICOS ligand/B7-h2  Protein, Antibody, ELISA Kit, cDNA Clone

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Expression host: Human Cells  
11559-H08H-200
11559-H08H-100
200 µg 
100 µg 
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Expression host: Human Cells  
11559-H02H-200
11559-H02H-100
200 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
50190-M03H-200
50190-M03H-100
200 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
50190-M08H-200
50190-M08H-100
200 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
81346-R08H-50
81346-R08H-200
50 µg 
200 µg 
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Expression host: Human Cells  
90800-C08H-20
90800-C08H-100
20 µg 
100 µg 
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ICOSL/ICOS ligand/B7-h2 Related Area

ICOSL/ICOS ligand/B7-h2 Related Pathways

    ICOSL/ICOS ligand/B7-h2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    ICOSL/ICOS ligand/B7-h2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    ICOSL/ICOS ligand/B7-h2 Summary & Protein Information

    ICOSL/ICOS ligand/B7-h2 Background

    Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

    ICOSL/ICOS ligand/B7-h2 Alternative Name

    ICOSL/ICOS ligand/B7-h2 Related Studies

  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"