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ICOS/AILIM/CD278  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10344-H03H-50
10344-H03H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50466-M02H-200
50466-M02H-100
200 µg 
100 µg 
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Expression host: Human Cells  
80381-R02H-50
80381-R02H-100
50 µg 
100 µg 
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ICOS/AILIM/CD278 Related Area

ICOS/AILIM/CD278 Related Pathways

    ICOS/AILIM/CD278 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    ICOS/AILIM/CD278 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    ICOS/AILIM/CD278 Summary & Protein Information

    ICOS/AILIM/CD278 Background

    Subunit structure: Homodimer; disulfide-linked. {ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.
    Subcellular location: Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; Isoform 2: Secreted {ECO:0000305}.
    Tissue specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.
    Induction: By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation. {ECO:0000269|PubMed:11169414}.
    Post-translational: N-glycosylated. {ECO:0000269|PubMed:11169414}.
    Involvement in disease: DISEASE: Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:12577056}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.

    ICOS/AILIM/CD278 Alternative Name

    AILIM,CD278,CVID1, [homo-sapiens]
    AILIM,CD278,ICOS,MGC39850, [human]
    AILIM,CCLP,CH29-120A16.4,CRP-1,H4,Icos,Ly115, [mouse]
    CCLP,AILIM,CRP-1,Ly115,H4, [mus-musculus]

    ICOS/AILIM/CD278 Related Studies

  • Coyle AJ, et al. (2004) The role of ICOS and other costimulatory molecules in allergy and asthma. Springer Semin Immunopathol. 25(3-4): 349-59.
  • Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.
  • van Berkel ME, et al. (2006) CD28 and ICOS: similar or separate costimulators of T cells Immunol Lett. 105(2): 115-22.
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