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HVEM/TNFRSF14/CD270  Protein, Antibody, ELISA Kit, cDNA Clone

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Expression host: Human Cells  
10334-H03H-200
10334-H03H-100
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Expression host: Human Cells  
10334-H08H-200
10334-H08H-100
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Expression host: Human Cells  
10567-M03H-200
10567-M03H-100
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Expression host: CHO Stable Cells  
10567-M03S-200
10567-M03S-100
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Expression host: Human Cells  
90109-C02H-50
90109-C02H-100
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HVEM/TNFRSF14/CD270 Related Area

HVEM/TNFRSF14/CD270 Related Pathways

HVEM/TNFRSF14/CD270 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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HVEM/TNFRSF14/CD270 Summary & Protein Information

HVEM/TNFRSF14/CD270 Background

Subunit structure: Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:16169851, ECO:0000269|PubMed:9153189, ECO:0000269|PubMed:9162022, ECO:0000269|PubMed:9696799}.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue specificity: Widely expressed, with the highest expression in lung, spleen and thymus.
Post-translational: N-glycosylated. {ECO:0000269|PubMed:16169851}.
Sequence similarity: Contains 3 TNFR-Cys repeats. {ECO:0000255|PROSITE-ProRule:PRU00206}.
General information above from UniProt

Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

HVEM/TNFRSF14/CD270 Alternative Name

TR2,ATAR,HVEA,HVEM,CD270,LIGHTR, [homo-sapiens]
ATAR,HVEA,HVEM,LIGHTR,RP3-395M20.6,TNFRSF14,TR2, [human]
Atar,HveA,Hvem,MGC123498,MGC123499,RP24-89N4.1,Tnfrs14,Tnfrsf14, [mouse]
Atar,HveA,Hvem,Tnfrs14, [mus-musculus]

HVEM/TNFRSF14/CD270 Related Studies

  • Murphy KM, et al. (2006) Balancing co-stimulation and inhibition with BTLA and HVEM. Nat Rev Immunol. 6(9): 671-81.
  • Heo SK, et al. (2007) HVEM signaling in monocytes is mediated by intracellular calcium mobilization. J Immunol. 179(9): 6305-10.
  • Steinberg MW, et al. (2008) A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 205(6): 1463-76.
  • Pasero C, et al. (2009) A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production. Eur J Immunol. 39(9): 2502-14.
  • Cheung TC. Modulation of T cell proliferation through the LIGHT-HVEM-BTLA cosignaling pathway. Recent Pat DNA Gene Seq. 3(3): 177-82.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"