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G-CSF/CSF3  Protein, Antibody, ELISA Kit, cDNA Clone

Description:   
Expression host: E. coli  
10007-HNCE-5
10007-HNCE-20
10007-HNCE-100
5 µg 
20 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
10007-H01H-5
10007-H01H-20
10007-H01H-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
Description:   
Expression host: Human Cells  
10007-HNCH-5
10007-HNCH-20
10007-HNCH-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1

G-CSF/CSF3 Related Area

G-CSF/CSF3 Related Pathways

    G-CSF/CSF3 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    G-CSF/CSF3 Summary & Protein Information

    G-CSF/CSF3 Background

    Gene Summary: The protein encoded by CSF3 gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for CSF3 gene. [provided by RefSeq, May 2010]
    General information above from NCBI
    Subunit structure: Monomer. {ECO:0000269|PubMed:10537111, ECO:0000269|PubMed:16492764}.
    Subcellular location: Secreted.
    Post-translational: O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).
    Sequence similarity: Belongs to the IL-6 superfamily. {ECO:0000305}.
    General information above from UniProt

    Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial cells. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of alpha-helical motifs of the former and two fibronectin type III as well as an immunoglobulin-like domain of the latter. Recent animal studies have also revealed that G-CSF activates multiple signaling pathways, such as Akt and also the Janus family kinase-2 and signal transducer and activation of transcription-3 (Jak2-STAT3) pathway, thereby promoting survival, proliferation, differentiation and mobilisation of haematopoietic stem and progenitor cells. G-CSF is a cytokine that have been demonstrated to improve cardiac function and perfusion in myocardial infarction. And it was initially evaluated as a stem cell mobilizer and erythropoietin as a cytoprotective agent. G-CSF prevents left ventricular remodeling after myocardial infarction by decreasing cardiomyocyte death and by increasing the number of blood vessels, suggesting the importance of direct actions of G-CSF on the myocardium rather than through mobilization and differentiation of stem cells. Accordingly, recombinant human (rh)G-CSF has been extensively used in clinical haematology and oncology to enable bone marrow transplantation or to treat chemotherapy-associated neutropenia. In preclinical study, G-CSF improved cardiac function and perfusion by angiomyogenesis and protection of cardiomyocytes in myocardial infarction.

    G-CSF/CSF3 Alternative Name

    G-CSF/CSF3 Related Studies

  • Takano H, et al. (2007) G-CSF therapy for acute myocardial infarction. Trends Pharmacol Sci. 28(10): 512-7.
  • Klocke R, et al. (2008) Granulocyte colony-stimulating factor (G-CSF) for cardio- and cerebrovascular regenerative applications. Curr Med Chem. 15(10): 968-77.
  • Kang HJ, et al. (2008) G-CSF- and erythropoietin-based cell therapy: a promising strategy for angiomyogenesis in myocardial infarction. Expert Rev Cardiovasc Ther. 6(5): 703-13.
  • Beekman R, et al. (2010) G-CSF and its receptor in myeloid malignancy. Blood. 115(25): 5131-6.
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