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Frizzled-10/FZD10 (CD350)  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
16045-H02H-50
16045-H02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
16045-H08H-50
16045-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50568-M02H-50
50568-M02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50568-M08H-20
50568-M08H-100
20 µg 
100 µg 
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Frizzled-10/FZD10 (CD350) Related Area

Frizzled-10/FZD10 (CD350) Related Pathways

Frizzled-10/FZD10 (CD350) Related Protein, Antibody, cDNA Gene, and ELISA Kits

Frizzled-10/FZD10 (CD350) Related Protein, Antibody, cDNA Gene, and ELISA Kits

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Frizzled-10/FZD10 (CD350) Summary & Protein Information

Frizzled-10/FZD10 (CD350) Background

Gene Summary: This FZD10 gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]
General information above from NCBI
Subunit structure: Interacts with MYOC. {ECO:0000269|PubMed:19188438}.
Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. {ECO:0000250}.; The FZ domain is involved in binding with Wnt ligands. {ECO:0000250}.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue specificity: Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.
Post-translational: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
Sequence similarity: Belongs to the G-protein coupled receptor Fz/Smo family. {ECO:0000305}.; Contains 1 FZ (frizzled) domain. {ECO:0000255|PROSITE-ProRule:PRU00090}.
General information above from UniProt

Mouse Frizzled-10, also known as Fz-10, CD350 and FZD10, is a multi-pass membrane protein which belongs to the G-protein coupled receptor Fz/Smo family. Frizzled-10 / FZD10 is abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. It is weakly expressed in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. Frizzled-10 / FZD10 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Frizzled-10 / FZD10 may also be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Frizzled-10/FZD10 (CD350) Alternative Name

Frizzled-10/FZD10 (CD350) Related Studies

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