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IRTA1/FCRL4  Protein, Antibody, ELISA Kit, cDNA Clone

IRTA1/FCRL4 Related Area

IRTA1/FCRL4 Related Pathways

    IRTA1/FCRL4 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    IRTA1/FCRL4 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    IRTA1/FCRL4 Summary & Protein Information

    IRTA1/FCRL4 Background

    Subcellular location: Cell membrane {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}.
    Tissue specificity: Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level). {ECO:0000269|PubMed:11290337, ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:12881317, ECO:0000269|PubMed:16079106, ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}.
    Post-translational: Phosphorylated on cytoplasmic tyrosines upon activation. {ECO:0000269|PubMed:14597715}.
    Involvement in disease: DISEASE: Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).; DISEASE: Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
    Sequence similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    IRTA1/FCRL4 Alternative Name

    CD307d,FCRH4,IGFP2,IRTA1, [Human]

    IRTA1/FCRL4 Related Studies

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