Subunit structure: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Sequence similarity: Belongs to the CD3Z/FCER1G family. Contains 1 ITAM domain.C