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Epidermal Growth Factor/EGF  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10605-H01H-500
10605-H01H-100
10605-H01H-1
500 µg 
100 µg 
1 mg 
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Expression host: E. coli  
10605-HNAE-500
10605-HNAE-100
10605-HNAE-1
500 µg 
100 µg 
1 mg 
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Expression host: Human Cells  
50482-M08H1-50
50482-M08H1-20
50 µg 
20 µg 
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Description: Active  
Expression host: Human Cells  
50482-M01H-500
50482-M01H-100
50482-M01H-1
500 µg 
100 µg 
1 mg 
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Description: Active  
Expression host: Human Cells  
50482-MNCH-500
50482-MNCH-100
50482-MNCH-1
500 µg 
100 µg 
1 mg 
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Expression host: Yeast  
50482-MNAY-500
50482-MNAY-100
50482-MNAY-1
500 µg 
100 µg 
1 mg 
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Expression host: E. coli  
80446-RNAE-500
80446-RNAE-100
80446-RNAE-1
500 µg 
100 µg 
1 mg 
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Description: Active  
Expression host: E. coli  
70013-D07E-500
70013-D07E-100
70013-D07E-1
500 µg 
100 µg 
1 mg 
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Epidermal Growth Factor/EGF Related Area

Epidermal Growth Factor/EGF Related Pathways

Epidermal Growth Factor/EGF Related Protein, Antibody, cDNA Gene, and ELISA Kits

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Epidermal Growth Factor/EGF Summary & Protein Information

Epidermal Growth Factor/EGF Background

Subunit structure: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). {ECO:0000250, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21029725, ECO:0000269|PubMed:21439629}.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed in kidney, salivary gland, cerebrum and prostate. {ECO:0000269|PubMed:17671655}.
Post-translational: O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor). {ECO:0000269|PubMed:22171320}.
Involvement in disease: DISEASE: Hypomagnesemia 4 (HOMG4) [MIM:611718]: A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. {ECO:0000269|PubMed:17671655}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Contains 9 EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00076}.; Contains 9 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}.
General information above from UniProt

EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bonds. As a low-molecular-weight polypeptide, EGF was first purified from the mouse submandibular gland, but since then it was found in many human tissues including submandibular gland, parotid gland. It can also be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Salivary EGF, which seems also regulated by dietary inorganic iodine, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. EGF acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation.

Epidermal Growth Factor/EGF Alternative Name

URG,HOMG4, [homo-sapiens]
Epidermal Growth Factor, [Human]
AI790464,Egf, [mouse]
AI790464, [mus-musculus]

Epidermal Growth Factor/EGF Related Studies

  • Chen JX, et al. (2011) Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells. Mol Cell Biochem. 358(1-2):67-73.
  • Guo Y, et al. (2012) Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer. Oncol Rep. 27(1):286-92.
  • Kim S, et al. (2012) Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells. Cancer Lett. 314(2):147-54.
  • Chatterton RT Jr, et al. (2010) Breast ductal lavage for assessment of breast cancer biomarkers. Horm Cancer. 1(4):197-204.
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