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DKK1/Dkk-1  Protein, Antibody, ELISA Kit, cDNA Clone

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Expression host: Human Cells  
10170-H08H-5
10170-H08H-20
10170-H08H-100
5 µg 
20 µg 
100 µg 
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Expression host: Human Cells  
57248-M08H-50
57248-M08H-10
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10 µg 
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Description: Active  
Expression host: Human Cells  
11089-K08H-5
11089-K08H-20
11089-K08H-100
5 µg 
20 µg 
100 µg 
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  • Slide 1
Description: Active  
Expression host: Human Cells  
11089-K05H-5
11089-K05H-20
11089-K05H-100
5 µg 
20 µg 
100 µg 
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  • Slide 1

DKK1/Dkk-1 Related Area

DKK1/Dkk-1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

DKK1/Dkk-1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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DKK1/Dkk-1 Summary & Protein Information

DKK1/Dkk-1 Background

Subunit structure: Interacts with LRP6. Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling. {ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:19746449, ECO:0000269|PubMed:20093360, ECO:0000269|PubMed:22000856}.
Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6. {ECO:0000250}.
Subcellular location: Secreted.
Tissue specificity: Placenta.
Sequence similarity: Belongs to the dickkopf family. {ECO:0000305}.
General information above from UniProt

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

DKK1/Dkk-1 Alternative Name

SK,DKK-1, [homo-sapiens]
S,Dickkopf 1,DKK1,DKK-1,hDKK 1,SK, [human]
mdkk-1, [mus-musculus]

DKK1/Dkk-1 Related Studies

  • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
  • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"