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Calreticulin  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
13539-H02H-50
13539-H02H-20
50 µg 
20 µg 
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Expression host: Human Cells  
13539-H08H-50
13539-H08H-20
50 µg 
20 µg 
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Calreticulin Related Area

Calreticulin Related Pathways

    Calreticulin Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Calreticulin Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    Calreticulin Summary & Protein Information

    Calreticulin Background

    Subunit structure: Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and C9orf9 (By similarity). Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Interacts with PPIB. {ECO:0000250|UniProtKB:P14211, ECO:0000250|UniProtKB:P18418, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:19154346, ECO:0000269|PubMed:20801878, ECO:0000269|PubMed:21423620, ECO:0000269|PubMed:8666824}.
    Domain: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.; The interaction with glycans occurs through a binding site in the globular lectin domain.; The zinc binding sites are localized to the N-domain.; Associates with PDIA3 through the tip of the extended arm formed by the P-domain.
    Subcellular location: Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen {ECO:0000250}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.
    Sequence similarity: Belongs to the calreticulin family. {ECO:0000305}.
    General information above from UniProt

    Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal. Located in storage compartments associated with the endoplasmic reticulum, calreticulin also binds to misfolded proteins and prevents them from being exported from the endoplasmic reticulum to the golgi apparatus. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin reduces the binding of androgen receptor to its hormone-responsive DNA element and inhibits androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Therefore, calreticulin acts as a significant modulator of the regulation of gene transcription by nuclear hormone receptors.

    Calreticulin Alternative Name

    RO,CRT,SSA,cC1qR,HEL-S-99n, [homo-sapiens]
    CALR,calregulin,Calreticulin,calreticulin),cC1qR,CRP55,CRT,endoplasmic reticulum resident protein 60,ERp60,grp60,HACBP,RO,Sicca syndrome antigen A (autoantigen Ro,SSA, [human]
    Calr,Calregulin,Calreticulin,CRP55,CRT,endoplasmic reticulum resident protein 60,ERp60,HACBP, [mouse]
    CRT,Calregulin, [mus-musculus]

    Calreticulin Related Studies

  • Michalak M, et al. (2002) Calreticulin in cardiac development and pathology. Biochim Biophys Acta. 1600(1-2):32-7.
  • Chao MP, et al. (2010) Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med. 2(63):63ra94.
  • Andrin, C, et al. (1998) Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules. Biochemistry. 37(29):10386-94.
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