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MCSF Receptor/CSF1R/CD115  Protein, Antibody, ELISA Kit, cDNA Clone

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Expression host: Human Cells  
10161-H03H-200
10161-H03H-100
200 µg 
100 µg 
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Expression host: Human Cells  
10161-HCCH-200
10161-HCCH-100
200 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
10161-H08H-50
10161-H08H-100
50 µg 
100 µg 
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Expression host: Baculovirus-Insect Cells  
10161-H20B1-50
10161-H20B1-20
50 µg 
20 µg 
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Expression host: Baculovirus-Insect Cells  
10161-H20B2-50
10161-H20B2-20
50 µg 
20 µg 
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Description: Active  
Expression host: Human Cells  
50059-M08H-50
50059-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50059-M03H-50
50059-M03H-100
50 µg 
100 µg 
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Expression host: Human Cells  
80447-R08H-50
80447-R08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
80447-R02H-50
80447-R02H-100
50 µg 
100 µg 
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MCSF Receptor/CSF1R/CD115 Related Area

MCSF Receptor/CSF1R/CD115 Related Pathways

    MCSF Receptor/CSF1R/CD115 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    MCSF Receptor/CSF1R/CD115 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    MCSF Receptor/CSF1R/CD115 Summary & Protein Information

    MCSF Receptor/CSF1R/CD115 Background

    Gene Summary: The protein encoded by CSF1R gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in CSF1R gene have been associated with a predisposition to myeloid malignancy. The first intron of CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
    General information above from NCBI

    M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.

    MCSF Receptor/CSF1R/CD115 Alternative Name

    MCSF Receptor/CSF1R/CD115 Related Studies

  • Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
  • Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
  • Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
  • Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
  • Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"