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CEACAM5/CEA/CD66e  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
11077-H03H-50
11077-H03H-100
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Expression host: Human Cells  
11077-H08H-50
11077-H08H-100
50 µg 
100 µg 
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CEACAM5/CEA/CD66e Related Pathways

    CEACAM5/CEA/CD66e Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CEACAM5/CEA/CD66e Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CEACAM5/CEA/CD66e Summary & Protein Information

    CEACAM5/CEA/CD66e Background

    Subunit structure: Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. {ECO:0000269|PubMed:18086185}.
    Subcellular location: Cell membrane {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185}.
    Tissue specificity: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
    Post-translational: Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
    Sequence similarity: Belongs to the immunoglobulin superfamily. CEA family. {ECO:0000305}.; Contains 7 Ig-like (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.

    CEACAM5/CEA/CD66e Alternative Name

    CEA,CD66e, [homo-sapiens]
    CD66e,CEACAM5,DKFZp781M2392,CEA, [human]
    1600029H12Rik,Psg30, [Mouse]
    Psg30,1600029H12Rik, [mus-musculus]

    CEACAM5/CEA/CD66e Related Studies

  • Baczyska D, et al. (2003) The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression. Cell Mol Biol Lett. 8(2): 471-86.
  • Blumenthal RD, et al. (2005) Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res. 65(19): 8809-17.
  • Liebig B, et al. (2005) Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Cancer Lett. 223(1): 159-67.
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