Quick Order

Home>CEACAM1
Text Size:AAA

CEACAM‑1/CD66a  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10822-H08H-50
10822-H08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
10822-H03H-50
10822-H03H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
50571-M02H-50
50571-M02H-200
50 µg 
200 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
50571-M08H-50
50571-M08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
80224-R08H-50
80224-R08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

CEACAM‑1/CD66a Related Area

CEACAM‑1/CD66a Related Pathways

    CEACAM‑1/CD66a Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CEACAM‑1/CD66a Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Featured Reagent Products

    CEACAM‑1/CD66a Summary & Protein Information

    CEACAM‑1/CD66a Background

    Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted.; Isoform 4: Secreted.; Isoform 5: Cell membrane; Single-pass type I membrane protein.; Isoform 6: Cell membrane; Single-pass type I membrane protein.; Isoform 7: Cell membrane; Single-pass type I membrane protein.; Isoform 8: Cell membrane; Single-pass type I membrane protein. Note=Localizes to sites of cell-cell contact.
    Sequence similarity: Belongs to the immunoglobulin superfamily. CEA family. {ECO:0000305}.; Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

    CEACAM‑1/CD66a Alternative Name

    BGP,BGP1,BGPI, [homo-sapiens]
    BGP,BGP1,BGPI,CD66a,CEACAM1, [human]
    bb-1,Bgp,Bgp1,Cc1,C-CAM,CD66a,Cea1,Cea-1,Cea7,Cea-7,Ceacam1,Hv2,Hv-2,mCEA1,Mhv-1,MHVR,MHVR1,mmCGM1,mmCGM1a,mmCGM2, [mouse]
    CC1,Bgp,Hv2,Bgp1,Cea1,Cea7,Hv-2,MHVR,bb-1,C-CAM,CD66a,Cea-1,Cea-7,MHVR1,Mhv-1,mCEA1,mmCGM1,mmCGM2,mmCGM1a, [mus-musculus]

    CEACAM‑1/CD66a Related Studies

  • Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.
  • Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.
  • Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"