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CDKL5  Protein, Antibody, ELISA Kit, cDNA Clone

CDKL5 Related Area

CDKL5 Related Pathways

    CDKL5 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CDKL5 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CDKL5 Summary & Protein Information

    CDKL5 Background

    Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
    Subunit structure: Interacts with MECP2. {ECO:0000269|PubMed:15917271}.
    Subcellular location: Nucleus {ECO:0000269|PubMed:16935860}.
    Tissue specificity: Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis.
    Post-translational: Autophosphorylated.
    Involvement in disease: DISEASE: Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).; DISEASE: Epileptic encephalopathy, early infantile, 2 (EIEE2) [MIM:300672]: A severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients with epileptic encephalopathy early infantile type 2 manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. However, EIEE2 and Rett syndrome are considered two distinct entities. {ECO:0000269|PubMed:12736870, ECO:0000269|PubMed:15492925, ECO:0000269|PubMed:15499549, ECO:0000269|PubMed:15689447, ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16015284, ECO:0000269|PubMed:16611748, ECO:0000269|PubMed:17993579, ECO:0000269|PubMed:18790821, ECO:0000269|PubMed:18809835, ECO:0000269|PubMed:19241098, ECO:0000269|PubMed:19253388, ECO:0000269|PubMed:24564546}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
    General information above from UniProt

    CDKL5 Alternative Name

    ISSX,STK9,EIEE2, [homo-sapiens]
    EIEE2,ISSX,STK9, [Human]
    BC038161,Stk9, [Mouse]
    Stk9,BC038161, [mus-musculus]

    CDKL5 Related Studies

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