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CDK8  Protein, Antibody, ELISA Kit, cDNA Clone

CDK8 Related Area

CDK8 Related Pathways

CDK8 Related Protein, Antibody, cDNA Gene, and ELISA Kits

CDK8 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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CDK8 Summary & Protein Information

CDK8 Background

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:10993082}.; ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. {ECO:0000269|PubMed:10993082}.
Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Subunit structure: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1. {ECO:0000269|PubMed:10024883, ECO:0000269|PubMed:15175163, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:17000779, ECO:0000269|PubMed:21806996, ECO:0000269|PubMed:9734358}.
Subcellular location: Nucleus {ECO:0000305}.
Sequence similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

CDK8 Alternative Name

K35, [homo-sapiens]

CDK8 Related Studies

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