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CDK16/PCTK1/PCTAIRE1  Protein, Antibody, ELISA Kit, cDNA Clone

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    CDK16/PCTK1/PCTAIRE1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CDK16/PCTK1/PCTAIRE1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CDK16/PCTK1/PCTAIRE1 Summary & Protein Information

    CDK16/PCTK1/PCTAIRE1 Background

    Gene Summary: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
    General information above from NCBI
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.
    Subunit structure: Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Interacts with NSF. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity). Interacts with BRSK2. Interacts with CCNY; this increases the CDK16 kinase activity. {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.
    Subcellular location: Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.
    Tissue specificity: Detected in pancreas islets (at protein level). Detected in brain and pancreas. {ECO:0000269|PubMed:22798068}.
    Post-translational: Phosphorylation at Ser-153 inhibits kinase activity. {ECO:0000269|PubMed:22798068}.
    Sequence similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
    General information above from UniProt

    CDK16/PCTK1/PCTAIRE1 Alternative Name

    CDK16/PCTK1/PCTAIRE1 Related Studies

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