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CDC37  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Baculovirus-Insect Cells  
10647-H09B-50
10647-H09B-20
50 µg 
20 µg 
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Expression host: Baculovirus-Insect Cells  
50826-M20B-20
50826-M20B-100
20 µg 
100 µg 
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Expression host: Baculovirus-Insect Cells  
50826-MNCB-20
50826-MNCB-100
20 µg 
100 µg 
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CDC37 Related Area

CDC37 Related Pathways

    CDC37 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CDC37 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CDC37 Summary & Protein Information

    CDC37 Background

    Subunit structure: Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1. {ECO:0000269|PubMed:11036079, ECO:0000269|PubMed:11085988, ECO:0000269|PubMed:9150368, ECO:0000269|PubMed:9482106}.
    Subcellular location: Cytoplasm {ECO:0000269|PubMed:9482106}.
    Post-translational: Constitutively sumoylated by UBE2I. {ECO:0000269|PubMed:17709345}.
    Sequence similarity: Belongs to the CDC37 family. {ECO:0000305}.
    General information above from UniProt

    CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.

    CDC37 Alternative Name

    P50CDC37, [homo-sapiens]
    CDC37,P50CDC37, [human]
    Cdc37,p50,p50Cdc37, [mouse]
    p50,p50Cdc37, [mus-musculus]

    CDC37 Related Studies

  • Dai K, et al. (1996) P hysical Interaction of Mammalian CDC37 with CDK4. The journal of biological chemistry. 271: 22030-4.
  • Pearl LH, et al. (2005) Hsp90 and Cdc37-a chaperone cancer conspiracy. Current opinion in genetics development. 15 (1): 55-61.
  • Chen GQ, et al. (2002) TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90. Molecular cell. 9 (2): 401-10.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"