Quick Order

Home>CD93
Text Size:AAA

CD93/C1qR  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
12589-H02H-50
12589-H02H-20
50 µg 
20 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
12589-H08H-50
12589-H08H-20
50 µg 
20 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
80207-R08H-50
80207-R08H-200
50 µg 
200 µg 
Add to Cart
  • Slide 1

CD93/C1qR Related Area

CD93/C1qR Related Pathways

    CD93/C1qR Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CD93/C1qR Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Featured Reagent Products

    CD93/C1qR Summary & Protein Information

    CD93/C1qR Background

    Subunit structure: Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q receptor. {ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:9233640}.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Tissue specificity: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
    Post-translational: N- and O-glycosylated. {ECO:0000269|PubMed:10092817}.
    Sequence similarity: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.; Contains 5 EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00076}.
    General information above from UniProt

    CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.

    CD93/C1qR Alternative Name

    C1QR1,C1qRP,CDw93,ECSM3,MXRA4,C1qR(P),dJ737E23.1, [homo-sapiens]
    C1qR,C1qR(P),C1qRP,CD93,MXRA4,C1QR1,CDw93,dJ737E23.1,ECSM3, [human]
    6030404G09Rik,AA145088,AA4.1,AW555904,C1qR,C1qr1,Cd93,Ly68,RP23-70N3.4,C1qrp, [mouse]
    Ly68,AA4.1,C1qr1,C1qrp,AA145088,AW555904,6030404G09Rik, [mus-musculus]

    CD93/C1qR Related Studies

  • Bohlson SS, et al. (2005) CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol. 175(2): 1239-47.
  • Norsworthy PJ, et al. (2004) Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol. 172(6): 3406-14.
  • Chevrier S, et al. (2009) CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci U S A. 106(10): 3895-900.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"