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CD89/FCAR  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10414-H08H-50
10414-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
80014-R08H-50
80014-R08H-100
50 µg 
100 µg 
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CD89/FCAR Related Area

CD89/FCAR Related Pathways

    CD89/FCAR Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CD89/FCAR Summary & Protein Information

    CD89/FCAR Background

    Gene Summary: This CD89 gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. CD89 interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Subunit structure: Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2. {ECO:0000269|PubMed:12768205, ECO:0000269|PubMed:7522255}.
    Subcellular location: Isoform A.1: Cell membrane; Single-pass type I membrane protein.; Isoform A.2: Cell membrane; Single-pass type I membrane protein.; Isoform A.3: Cell membrane; Single-pass type I membrane protein.; Isoform B: Secreted.; Isoform B-delta-S2: Secreted.
    Tissue specificity: Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. {ECO:0000269|PubMed:8666819, ECO:0000269|PubMed:8836118}.
    Sequence similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

    CD89/FCAR Alternative Name

    CD89/FCAR Related Studies

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