Quick Order

Home>CD70
Text Size:AAA

CD70/CD27L/TNFSF7  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10780-H01H-50
10780-H01H-5
10780-H01H-100
50 µg 
5 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
51129-M04H-50
51129-M04H-200
50 µg 
200 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
80161-R01H-50
80161-R01H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
80161-R07H-50
80161-R07H-20
50 µg 
20 µg 
Add to Cart
  • Slide 1

CD70/CD27L/TNFSF7 Related Area

CD70/CD27L/TNFSF7 Related Pathways

CD70/CD27L/TNFSF7 Related Protein, Antibody, cDNA Gene, and ELISA Kits

Featured Reagent Products

CD70/CD27L/TNFSF7 Summary & Protein Information

CD70/CD27L/TNFSF7 Background

Subunit structure: Homotrimer. {ECO:0000305}.
Subcellular location: Membrane; Single-pass type II membrane protein.
Sequence similarity: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.

CD70/CD27L/TNFSF7 Alternative Name

CD27L,CD27LG,TNFSF7, [homo-sapiens]
CD27L,CD27LG,CD70,TNFSF7, [human]
Cd27l,CD27LG,Tnfsf7, [Mouse]
Cd27l,CD27LG,Tnfsf7, [mus-musculus]

CD70/CD27L/TNFSF7 Related Studies

  • Adam PJ, et al. (2006) CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Br J Cancer. 95(3): 298-306.
  • Keller AM, et al. (2007) Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules. Proc Natl Acad Sci U S A. 104(14): 5989-94.
  • Grewal IS. (2008) CD70 as a therapeutic target in human malignancies. Expert Opin Ther Targets. 12(3): 341-51.
  • Boursalian TE, et al. (2009) Targeting CD70 for human therapeutic use. Adv Exp Med Biol. 647: 108-19.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"