CD59a / Protectin
Protein, Antibody, ELISA Kit, cDNA Clone
Expression host: Human Cells
CD59a / Protectin Related Area CD59a / Protectin Related Protein, Antibody, cDNA Gene, and ELISA Kits CD59a / Protectin Related Protein, Antibody, cDNA Gene, and ELISA Kits Featured Reagent Products CD59a / Protectin Background
Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins.It was found that the CD59/Protectin antigen is a small protein sometimes associated with larger components (45 and 80 kD) in urine. CD59/Protectin antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor; it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria.