Quick Order

Home>CD47
Text Size:AAA

CD47  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
12283-HCCH-50
12283-HCCH-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
12283-H02H-50
12283-H02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
57231-M08H-50
57231-M08H-200
50 µg 
200 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
80305-R02H-50
80305-R02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
80305-R08H-50
80305-R08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

CD47 Related Area

CD47 Related Pathways

    CD47 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CD47 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Featured Reagent Products

    CD47 Summary & Protein Information

    CD47 Background

    Subunit structure: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2. {ECO:0000250, ECO:0000269|PubMed:10549293, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453, ECO:0000269|PubMed:18657508}.
    Subcellular location: Cell membrane {ECO:0000269|PubMed:7691831}; Multi-pass membrane protein {ECO:0000269|PubMed:7691831}.
    Tissue specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
    Sequence similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

    CD47 Alternative Name

    IAP,OA3,MER6, [homo-sapiens]
    antigen identified by monoclonal antibody 1D8,antigenic surface determinant protein OA3,CD47 antigen (Rh-related antigen,CD47 glycoprotein,IAP,integrin associated protein,integrin-associated signal transducer,integrin-associated signal transducer),leukocyte surface antigen CD47,MER6,OA3,Rh-related antigen, [human]
    9130415E20Rik,AA407862,AI848868,AW108519,B430305P08Rik,IAP,integrin-associated protein,Itgp,leukocyte surface antigen CD47,Rh-related antigen, [mouse]
    IAP,Itgp,AA407862,AI848868,AW108519,9130415E20Rik,B430305P08Rik, [mus-musculus]

    CD47 Related Studies

  • Brown EJ, et al. (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11(3): 130-5.
  • Oldenborg PA. (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma. 45(7): 1319-27.
  • Kaczorowski DJ, et al. (2007) Targeting CD47: NO limit on therapeutic potential. Circ Res. 100(5): 602-3.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"