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CD40 Ligand/CD40L/CD154  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: E. coli  
10239-H08E-50
10239-H08E-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
10239-H01H-50
10239-H01H-5
10239-H01H-20
50 µg 
5 µg 
20 µg 
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Description: Active  
Expression host: Human Cells  
50327-M01H-50
50327-M01H-20
50 µg 
20 µg 
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Expression host: Human Cells  
80177-R01H-50
80177-R01H-20
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20 µg 
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Expression host: Human Cells  
70068-D04H-50
70068-D04H-100
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100 µg 
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Expression host: Human Cells  
70068-DNCH-50
70068-DNCH-20
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20 µg 
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Expression host: Human Cells  
90096-C01H-50
90096-C01H-100
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100 µg 
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CD40 Ligand/CD40L/CD154 Related Area

CD40 Ligand/CD40L/CD154 Related Pathways

CD40 Ligand/CD40L/CD154 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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CD40 Ligand/CD40L/CD154 Summary & Protein Information

CD40 Ligand/CD40L/CD154 Background

Gene Summary: The CD40L protein encoded by this CD40LG gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this CD40LG gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
General information above from NCBI
Subunit structure: Homotrimer.
Subcellular location: Cell membrane; Single-pass type II membrane protein.; CD40 ligand, soluble form: Secreted.
Tissue specificity: Specifically expressed on activated CD4+ T-lymphocytes.
Post-translational: The soluble form derives from the membrane form by proteolytic processing. {ECO:0000269|PubMed:8626375}.; N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.; Not O-glycosylated.
Involvement in disease: DISEASE: X-linked immunodeficiency with hyper-IgM 1 (HIGM1) [MIM:308230]: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. {ECO:0000269|PubMed:7532185, ECO:0000269|PubMed:7678782, ECO:0000269|PubMed:7679206, ECO:0000269|PubMed:7679801, ECO:0000269|PubMed:7717401, ECO:0000269|PubMed:8094231, ECO:0000269|PubMed:8550833, ECO:0000269|PubMed:8889581, ECO:0000269|PubMed:9150729, ECO:0000269|PubMed:9746782}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD154, also known as CD40 ligand or CD40L, is a member of the TNF superfamily. While CD154 was originally found on T cell surface, its expression has since been found on a wide variety of cells, including platelets, mast cells, macrophages and NK cells. CD154's ability is achieved through binding to the CD40 on antigen- presenting cells (APC). In the macrophage cells, the primary signal for activation is IFN-γ from Th1 type CD4 T cells. The secondary signal is CD40L on the T cell, which interacting with the CD40 molecules, helping increase the level of activation.

CD40 Ligand/CD40L/CD154 Alternative Name

CD40 Ligand/CD40L/CD154 Related Studies

  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Grewal IS, et al. (1998) CD40 and CD154 in cell-mediated immunity. Annual Review of Immunology. 16: 111-35.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"