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CD3e/CD3 epsilon  Protein, Antibody, ELISA Kit, cDNA Clone

Description:   
Expression host: Human Cells  
10977-H08H-50
10977-H08H-20
50 µg 
20 µg 
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Expression host: Human Cells  
10977-H03H-50
10977-H03H-20
50 µg 
20 µg 
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Expression host: Human Cells  
80452-R02H-20
80452-R02H-100
20 µg 
100 µg 
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Expression host: Human Cells  
70106-D02H-20
70106-D02H-100
20 µg 
100 µg 
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Expression host: Human Cells  
90047-C03H-20
90047-C03H-100
20 µg 
100 µg 
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Expression host: Human Cells  
90047-C02H-50
90047-C02H-20
50 µg 
20 µg 
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  • Slide 1
Expression host: Human Cells  
90047-C08H-50
90047-C08H-20
50 µg 
20 µg 
Add to Cart
  • Slide 1

CD3e/CD3 epsilon Related Area

CD3e/CD3 epsilon Related Pathways

    CD3e/CD3 epsilon Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CD3e/CD3 epsilon Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CD3e/CD3 epsilon Summary & Protein Information

    CD3e/CD3 epsilon Background

    Subunit structure: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. {ECO:0000269|PubMed:15136729, ECO:0000269|PubMed:15534202, ECO:0000269|PubMed:9698567}.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Involvement in disease: DISEASE: Immunodeficiency 18 (IMD18) [MIM:615615]: An autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. The severity is variable, encompassing both a mild immunodeficiency and severe combined immunodeficiency (SCID), resulting in early death without bone marrow transplantation in some patients. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell-positive, natural killer (NK) cell-positive phenotype, whereas T-cell development is not impaired in the mild form of IMD18. {ECO:0000269|PubMed:15546002, ECO:0000269|PubMed:8490660}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Contains 1 Ig-like (immunoglobulin-like) domain. {ECO:0000305}.; Contains 1 ITAM domain. {ECO:0000255|PROSITE-ProRule:PRU00379}.
    General information above from UniProt

    T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

    CD3e/CD3 epsilon Alternative Name

    T3E,TCRE,IMD18, [homo-sapiens]
    CD3E,CD3-epsilon,FLJ18683,T3E,TCRE, [human]
    Cd3,AI504783,CD3e,CD3epsilon,T3e, [mouse]
    CD3,T3e,AI504783,CD3epsilon, [mus-musculus]

    CD3e/CD3 epsilon Related Studies

  • Fischer A, et al. (2005) CD3 deficiencies. Curr Opin Allergy Clin Immunol. 5(6): 491-5.
  • Wang Y, et al. (2009) A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol. 7(12): e1000253.
  • Martnez-Martn N, et al. (2009) Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon. Sci Signal. 2(83): ra43.
  • Deford-Watts LM, et al. (2009) The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions. J Immunol. 183(2): 1055-64.
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