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CD3g/CD3 gamma  Protein, Antibody, ELISA Kit, cDNA Clone

CD3g/CD3 gamma Related Area

CD3g/CD3 gamma Related Pathways

    CD3g/CD3 gamma Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CD3g/CD3 gamma Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CD3g/CD3 gamma Summary & Protein Information

    CD3g/CD3 gamma Background

    Subunit structure: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. {ECO:0000269|PubMed:15136729}.
    Domain: A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Involvement in disease: DISEASE: Immunodeficiency 17 (IMD17) [MIM:615607]: An autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor dependent stimuli. The phenotype in some patients is reminiscent of severe combined immunodeficiency. {ECO:0000269|PubMed:1635567, ECO:0000269|PubMed:17277165}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Contains 1 Ig-like (immunoglobulin-like) domain. {ECO:0000305}.; Contains 1 ITAM domain. {ECO:0000255|PROSITE-ProRule:PRU00379}.
    General information above from UniProt

    CD3g/CD3 gamma Alternative Name

    T3G,IMD17,CD3-GAMMA, [homo-sapiens]
    T3g,Ctg3,Ctg-3, [mus-musculus]

    CD3g/CD3 gamma Related Studies

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